HARNESSING ADENOVIRUS IN CANCER IMMUNOTHERAPY: EVOKING CELLULAR IMMUNITY AND TARGETING DELIVERY IN CELL-SPECIFIC MANNER

Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner

Abstract Recombinant adenovirus (rAd) klaire labs ashwagandha regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been identified as potential cancer therapeutics.OAV presents advantages such as selective replication, oncolytic efficacy, and tumor microenvironment (TME) remodeling.In this

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Development of a repeat-exposure penile SHIV infection model in macaques to evaluate biomedical preventions against HIV.

Penile acquisition of HIV infection contributes substantially to the global epidemic.Our goal was to establish a preclinical macaque model of penile HIV infection for evaluating the efficacy of new HIV prevention modalities.Rhesus macaques were challenged once or twice weekly with consistent doses of SHIVsf162P3 (a chimeric simian-human immunodefic

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HAVoC, a bioinformatic pipeline for reference-based consensus assembly and lineage assignment for SARS-CoV-2 sequences

Abstract Background SARS-CoV-2 related research has increased in importance worldwide since December 2019.Several lycogel new variants of SARS-CoV-2 have emerged globally, of which the most notable and concerning currently are the UK variant B.1.1.7, the South African variant B1.351 and the Brazilian variant P.1.Detecting and monitoring novel varia

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